We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Notice of Extension of Expiration Date for PAR-14-342 "NIDCR Behavioral or Social Intervention Clinical Trial Planning Grant (R34)"
- Notice of Applicant Information Webinar for the Point-of-Care Technologies Research Network Centers (U54)
- Notice of a Pre-Application Webinar for RFA-CA-17-049, Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium (U54)
- Partnerships for Countermeasures Against Select Pathogens (R01)
- Consortium on Translational Research in Early Detection of Liver Cancer (Clinical and Research Centers (U01)