We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Cystic Fibrosis Research and Translation Centers (P30 Clinical Trial Optional)
- Using Data Analytics to Support Primary Care and Community Interventions to Improve Chronic Disease Prevention and Management and Population Health (R18)
- Behavioral and Social Research to Address Health Disparities in the U.S. (Admin Supp Clinical Trial Optional)
- NICHD Data and Specimen Hub (DASH) Releases New Functionality for Biospecimen Requests
- Notice of Change in the Number of Trainee Slots on NHGRI T32 Postdoctoral Training Program in Genomic Medicine Research