We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Notice of Change in Application Due Dates for RFA-NS-18-001 "Center Without Walls for Collaborative Research in the Epilepsies: Functional Evaluation of Human Genetic Variants (U54)"
- Notice of Expiration of PAR-16-433 "Support of NIGMS Program Project Grants (P01)"
- Collaborative Program Grant for Multidisciplinary Teams (RM1)
- BRAIN Initiative: Tools to target, identify and characterize non-neuronal cells in the brain (R01 Clinical Trial Not Allowed)
- Development of Valid Reliable Markers of Aging-Related Biologic Mechanisms for Human Studies (U01)