We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Notice of NIMH's Participation in PA-19-055 "Research Project Grant (Parent R01 Clinical Trial Required)
- Notice of NEI Withdrawal from Participation in PAR-19-055 "Research Project Grant (Parent R01 Clinical Trial Required)"
- Notice of NEI Participation in PAR-19-056 "Research Project Grant (Parent R01 Clinical Trial Not Allowed)"
- Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed)
- NIH to Host Second Informational Webinar on Proposed Key Provisions for a Future Draft Data Management and Sharing Policy