We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Additional Short-Term Administrative Relief to Institutions Impacted by Hurricanes Harvey, Irma, and Maria
- Notice of NIA Participation in PAR-17-486: "Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences (K18 Clinical Trial Required)"
- Request for Information on the Office of Disease Prevention Strategic Plan for Fiscal Years (FY) 20192023
- Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer (R01 Clinical Trial Optional)
- Using Information Technology to Support Systematic Screening and Treatment of Depression in Cancer (R21 Clinical Trial Optional)