We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Notice of Change to RFA-MH-18-706, Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R34- Clinical Trial Required)
- Notice of Changes in the Eligibility of Candidates Supported by the NIMH Administrative Supplement Program to Enable Continuity of Research Experiences of MD/PhDs during Clinical training (Admin Supp)
- Assuring Radiation Protection (U18)
- Renewal Applications: Centers of Excellence in Regulatory Science and Innovation
- Computational fluid dynamics (CFD) and discrete element modeling (DEM) approach for predictions of dry powder inhaler (DPI) drug delivery