We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Post-Stroke Vascular Contributions to Cognitive Impairment and Dementia (VCID) in the United States Including in Health Disparities Populations (U19 Clinical Trial not Allowed)
- Update to the NIH/AHRQ/NIOSH Policy on Post-Submission Materials
- Notice of Additional Receipt Dates for RFA-ES-16-005 "Mechanism for Time-Sensitive Opportunities in Environmental Health Sciences (R21)"
- Findings of Research Misconduct
- Notice of Removal of Matching Requirements for RFA-NS-18-041 Discovery of Biomarkers, Biomarker Signatures, and Endpoints for Pain (R61/R33 Clinical Trial Optional)