We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 Independent Clinical Trial Not Allowed)
- Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 Clinical Trial Required)
- (Re)Building a Kidney (UC2 Clinical Trial Not Allowed)
- Notice of Intent to Publish a Funding Opportunity Announcement for the Reissue NIDA Program Project Grant Applications (P01 Clinical Trial Optional)
- Notice of NIDA Participation in PAR-18-901, "Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43 Clinical Trial Optional)"