We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Sponsored Programs Administration Development (SPAD) Program (UC2 - Clinical Trial Not Allowed)
- Guidance on Posting Informed Consent Forms for NIH-Funded Clinical Trials
- Request for Information (RFI): The NINDS is Soliciting Input on Enhancing Neuroscience Research at Institutions with Emerging Neuroscience Programs
- PrEP for HIV Prevention among Substance Using Populations (R01 Clinical Trial Optional)
- Notice of Special Interest for Small Business Research in Genomics