We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Notice of Change to Key Dates in PA-17-291 "HIV Drug Resistance: Genotype-Phenotype-Outcome Correlations (R01)"
- Development, Integration, and Data Mining of Biomolecular and Cellular Networks for Discovering Druggable Targets for Alcohol Use Disorder and Alcohol-Induced Organ Damage
- Findings of Research Misconduct
- Revision: Ruth L. Kirschstein National Research Service Awards (NRSA) Predoctoral Stipends, Training Related Expenses, Institutional Allowance, and Tuition/Fees Effective for Fiscal Year 2017
- Academic Development of a Training Program for Good Laboratory Practices in High Containment Environments (U24)