We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Discovery of the Genetic Basis of Childhood Cancers and of Structural Birth Defects: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)
- Contraception Research Centers Program (U54 Clinical Trial Optional)
- Notice of Additional Funds Available for PAS-18-625, " Mechanistic investigations of psychosocial stress effects on opioid use patterns (R21- Clinical Trial Optional)"
- Notice of NINDS' Participation in NOT-AG-18-050 "Notice to Specify High-Priority Research Topic for PAR-19-070"
- Notice of Pre-Application Webinars for the HEAL Initiative: Back Pain Consortium (BACPAC) Research Program