We study ion translocating mechanisms (channels, exchangers and pumps) in health and disease. Our main focus is the KATP channel, which is responsible for metabolo-electrical coupling (the coupling of intracellular energy metabolism to membrane excitability and secretion). Using genetically engineered mouse models, we investigate the roles of roles for this channel in cardioprotection and the regulation of blood flow. We also pursue molecular studies to investigate regulation of channel function and trafficking by associated proteins.
NIH Funding Opportunities
- Limited Competition: RCMI Research Coordination Network (RRCN) (U54 Clinical Trial Not Allowed)
- NLM Information Resource Grants to Reduce Health Disparities (G08 Clinical Trial Not Allowed)
- Leveraging Electronic Medical Records for Psychiatric Genetic Research (R01 Clinical Trial Not Allowed)
- Leveraging Electronic Medical Records for Psychiatric Genetic Research (R01 (Collab) Clinical Trial Not Allowed)
- Notice of the Publication of an NIH Proposal to Amend the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules to Streamline Oversight of Human Gene Transfer Protocols