NIH Funding Opportunities

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Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
Updated: 3 hours 14 min ago

Non-Invasive Neurostimulation in AD/ADRD (R01 Clinical Trial Optional)

Fri, 06/14/2019 - 11:43
Funding Opportunity PAR-19-298 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies using non-invasive neurostimulation/neuromodulation in the treatment of Alzheimer's Disease (AD) or Alzheimer's disease-related dementias (ADRD). The goal of this FOA is to establish initial efficacy of neurostimulation/neuromodulation in the treatment of AD/ADRD or to refine these interventions for AD/ADRD patients. Multimodal or combination interventions are allowed, provided the focus and innovative component is neurostimulation.
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Mechanistic Basis of Diffuse White Matter Disease in Vascular Contributions to Cognitive Impairment and Dementia (VCID)(R01 Clinical Trial Not Allowed)

Fri, 06/14/2019 - 11:00
Funding Opportunity RFA-NS-19-039 from the NIH Guide for Grants and Contracts. (Reissue of RFA-NS-16-021, PAR-18-413) Diffuse brain white matter disease is highly prevalent in the elderly, and has been clinically associated with vascular contributions to cognitive impairment and dementia (VCID) in both men and women. Diffuse white matter disease is thought to include a variety of pathologies including demyelination and/or fiber loss due to multifocal infarction and local ischemia. It is often accompanied by arteriosclerosis in deep penetrating arteries, multiple infarcts in the basal ganglia, brainstem or cerebellum. Though most commonly extending out from the periventricular surfaces, it may also occur in subcortical white matter. Diffuse white matter disease is typically detected in clinical settings as hyperintensity on magnetic resonance imaging (MRI) or signal loss on computed tomography x-ray (CT) scan; diffuse white matter disease can be detected histologically as well, for example in human pathology and in studies using animal models. Despite the prevalence and potential significance of white matter disease for cerebrovascular disease etiology and cognitive outcomes, much remains to be learned about the cellular and molecular causes, regional vulnerability, and progression over time. The physiological consequences of diffuse white matter disease on local axon and neural circuit function are almost completely unknown. The purpose of this FOA is to address some of the many gaps in knowledge of the biologic mechanisms of the commonly occurring, cerebrovascular disease and age-related diffuse white matter disease at the molecular, cellular, tissue and brain circuit level. The ultimate goal of this fundamental research is to inform future efforts to reduce the burden of illness due to age-related vascular contributions to cognitive impairment and dementia.
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NIH Expanding Usage of Notices of Special Interest

Fri, 06/14/2019 - 02:57
Notice NOT-OD-19-107 from the NIH Guide for Grants and Contracts
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Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25 Clinical Trial Not Allowed)

Fri, 06/14/2019 - 02:49
Funding Opportunity RFA-ES-19-010 from the NIH Guide for Grants and Contracts. The goal of this NIEHS undergraduate research education R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce in the environmental health sciences. To this end, this funding opportunity announcement (FOA) encourages the development of creative educational activities with a primary focus on research experiences for undergraduates at the junior and senior level.
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Characterization of Marmosets as Models of Aging and Age-Related Diseases (U34 Clinical Trial Not Allowed)

Fri, 06/14/2019 - 02:27
Funding Opportunity RFA-AG-20-007 from the NIH Guide for Grants and Contracts. The primary aim of this Funding Opportunity Announcement (FOA) is to facilitate the characterization of the marmoset as a laboratory animal for research on aging and age-related diseases.
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"Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed)

Wed, 06/12/2019 - 10:59
Funding Opportunity RFA-TR-19-014 from the NIH Guide for Grants and Contracts. This FOA invites applications for projects designed to test the effectiveness of microphysiological systems (MPS), also called tissue chip, technology, for clinical trial frameworks by demonstrating their applied use in clinical trial planning and execution, addressing both safety and efficacy in late-stage preclinical studies. This approach is to provide evidence of the utility of tissue chip technology for precision medicine in informing trial design, establishing recruitment criteria and stratification of patient populations in identifying the best responders to candidate therapeutics.
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Notice to Allow Requests for Budget Increases for NINDS Research Program Award (R35)

Wed, 06/12/2019 - 02:38
Notice NOT-NS-19-058 from the NIH Guide for Grants and Contracts
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Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders (U24 Clinical Trial Not Allowed)

Tue, 06/11/2019 - 10:25
Funding Opportunity RFA-MH-20-215 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Institute of Mental Health (NIMH) seeks applications to develop, sustain, enhance, and enrich a centralized national biorepository for genetic studies of psychiatric disorders for facilitation and acceleration of the scientific understanding of the genetic risk architecture underlying mental disorders. This effort is expected to involve a functionally integrated, multi-disciplinary team that will provide for open sharing of biosamples and data resources through a single, centralized, national resource to advance basic and translational research in the genetics of mental disorders.
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Aging, Driving and Early Detection of Dementia (R01 Clinical Trial Optional)

Tue, 06/11/2019 - 08:43
Funding Opportunity RFA-AG-20-022 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to conduct new research on automobile technology for signaling early signs of cognitive impairment in older drivers.
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Clinical Studies of Mental Illness (Collaborative R01 Clinical Trial Optional)

Mon, 06/10/2019 - 12:47
Funding Opportunity PAR-19-297 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to support collaborative clinical studies, not involving treatment development, efficacy, or effectiveness trials. Primary areas of focus include mental health genetics, biomarker studies, and studies of mental illnesses (e.g., psychopathology, neurodevelopmental trajectories of psychopathology) also when associated with HIV/AIDS. Applicants should apply to this FOA when two or more sites are needed to complete the study. Accordingly, the collaborating studies share a specific protocol across the sites and are organized as such in order to increase sample size, accelerate recruitment, or increase sample diversity and representation. In studies with a large number of sites, it is expected that one site will be submitted as a coordinating R01 for data management and/or other centralized administration.
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Research to Understand and Inform Interventions that Promote the Research Careers of Individuals in the Biomedical Sciences (R01 - Clinical Trial Not Allowed)

Fri, 06/07/2019 - 12:58
Funding Opportunity PAR-19-295 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages solicits applications that propose research designed to test training, mentoring, and networking interventions intended to enhance research-oriented individuals' interest, motivation, persistence and preparedness for careers in the biomedical research workforce. Funded projects are expected to produce research findings that will guide the design and implementation of potential interventions in a variety of academic settings and career levels to enhance the diversity of the biomedical research workforce.
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Reminder: Expiration of FY2014 Grant Funds

Fri, 06/07/2019 - 11:23
Notice NOT-OD-19-111 from the NIH Guide for Grants and Contracts
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NIAID New Innovators Awards (DP2 Clinical Trial Not Allowed)

Fri, 06/07/2019 - 02:24
Funding Opportunity PAR-19-296 from the NIH Guide for Grants and Contracts. The NIAID New Innovator Awards supports post-doctoral and early stage investigators of exceptional creativity who propose highly innovative bold new research with the potential to produce a major impact on broad, important problems in biomedical research of priority to NIAID. Applications from individuals with diverse backgrounds and in any topic relevant to the mission of NIAID are welcome.
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Notice of NICHD's Participation in PAR-19-215, "Team-Based Design in Biomedical Engineering Education (R25 Clinical Trial Not Allowed)"

Thu, 06/06/2019 - 13:12
Notice NOT-HD-19-016 from the NIH Guide for Grants and Contracts
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